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Downy mildew, caused by Peronospora belbahrii, poses a significant threat to basil (Ocimum basilicum) crops. This study investigates the potential of Chromolaena odorata extract as a bioorganic therapy for Downy Mildew. The goal of this research based innovation is to determine the long-term and environmentally friendly potential of C. odorata extract as an alternative to synthetic fungicides for controlling Downy Mildew in basil, thereby contributing to SDGs 2 (Zero Hunger), 3 (Good Health and Well-being), and 15 (Life on Land). The leaves of C. odorata were collected and extracted, and the bioorganic solution produced was tested for antifungal efficacy against Peronospora belbahrii. During field investigations, C. odorata extract demonstrated significant antifungal activity against Peronospora belbahrii. The findings suggest that C. odorata extract with concentration 0.0003 g/mL has potential as a bio-organic treatment for Downy Mildew, which is consistent with SDG 12 (Responsible Consumption and Production) by supporting sustainable farming practices that reduce reliance on chemical inputs.