Virtual Booth

Oral infections such as candidiasis and dental plaque remain difficult to treat due to the formation of biofilms, which protect microorganisms from conventional therapies and contribute to antimicrobial resistance. This study explores the therapeutic potential of selected Syzygium species as natural sources of bioactive compounds with antimicrobial and antibiofilm properties. Plant leaves were extracted and analysed to identify compounds capable of inhibiting microbial growth and reducing biofilm formation. The extracts demonstrated significant antioxidant activity and antifungal effects, particularly against Candida species associated with oral infections. Among the isolated compounds, syzydyerin A showed remarkable antibiofilm activity, reducing biofilm formation by more than 80%. Molecular docking studies further suggested strong interactions between the compound and microbial targets, supporting its potential mechanism of action and relevance for future drug development. These findings highlight the value of underutilised medicinal plants as promising alternatives for combating resistant oral infections. Overall, this research contributes to the discovery of safer, plant-based therapeutic agents for improved oral and general health.