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Nile tilapia is a type of freshwater fish in the cichlid family and is an economically important fish in Thailand. It is commonly bought for commercial purposes or consumption, with popular dishes being grilled or fried tilapia. Before frying, the fish scales are often scraped off, and sometimes vendors may not know how to dispose of them properly. This leads to scales being discarded into rivers, causing water pollution, or being thrown away in various places. When decomposition begins, fish scales, as organic waste, emit a foul odor. Even when discarded and collected by waste trucks, they ultimately end up in landfills, accumulating and exacerbating the issue. Therefore, Nile tilapia scales have become a significant problem in organic waste disposal today. The Ministry of Natural Resources and Environment of Thailand reports that organic waste constitutes a substantial portion of the country’s waste, with 17.56 million tons of organic waste generated annually, accounting for 64% of total solid waste. Food waste is a global concern because its decomposition produces methane gas, which contributes to global warming 25 times more than carbon dioxide. Annually, approximately 1.3 billion tons of food waste are landfilled, causing pollution and contributing to 8% of all greenhouse gases. Additionally, Nile tilapia scales contain beneficial compounds such as calcium, which can be utilized in various applications, including supplements, fertilizers, or synthetic bones. This project aims to extract useful compounds like calcium from discarded fish scales to make them beneficial. This work aligns with the Sustainable Development Goals (SDGs), particularly Goal 3, which focuses on ensuring healthy lives and promoting well-being for all ages. It highlights the importance of health in various aspects and aims to ensure good health and well-being for everyone by addressing communicable and non-communicable diseases, maternal and child health, mental