NORSYAFINA AZNA BINTI MOHD RASDI Universiti Teknologi Mara Perlis
Natural plant-based hydrogels have gained increasing attention due to their potential antibacterial and therapeutic properties. This study aimed to formulate and evaluate a hydrogel containing Bidara (Ziziphus mauritiana) and curry leaf (Murraya koenigii) extracts for potential wound healing and topical antibacterial application. The leaves were extracted using methanol solvent through ultrasonic-assisted extraction (UAE) and concentrated using rotary evaporation to obtain crude extracts before being incorporated into a polymer-based hydrogel formulation. The antibacterial activity of the hydrogel was evaluated using the disc diffusion method, while the physical characteristics, including colour, texture, homogeneity, and spreadability, were also assessed. The results showed that the hydrogel containing Bidara and Curry leaf extracts exhibited antibacterial activity and demonstrated suitable physical properties for topical application. In conclusion, the formulated hydrogel has promising potential as a natural antibacterial topical agent, although further studies on stability, toxicity, and formulation optimization are recommended to enhance its effectiveness and safety.