Virtual Booth

Malabaricone C (MLC) is a ligand compound found in the pericarp of Myristica fragrans, commonly known as nutmeg. It has attracted much attention due to its various pharmacological actions such as antioxidant, anti-inflammatory, anticancer, and antidiabetic effects. In this study, the fluorescence activity of MLC by human serum albumin (HSA) was investigated. The fluorescent activity of MLC-HSA has been found to be dependent on factors such as pH, temperature and concentration. The resulting fluorescence spectra of MLC-HSA titrations, performed in phosphate buffer (pH 7.4) displayed progressive quenching of the fluorescence intensity of HSA with increasing MLC concentrations at all three tested temperatures (290, 300 and 310 K). According to the thermodynamic data of the binding reaction, hydrophobic interactions, hydrogen bonds, and van der Waals forces stabilized the MLC-HSA complex.