Virtual Booth

Diabetes is one of the major global health problems, and patients with this condition often require multiple medications. This increases cost, inconvenience, and the potential of side effects. A promising solution is that a single compound could serve many functions. This study assessed the potential of pyrrolidine-based compounds as multi-target inhibitors for two key targets for the treatment of hyperglycemia:  α-amylase and α-glucosidase. Pyrrolidine is well known in medicinal chemistry for its wide range of biological activities. However, its possible role as a multi-target inhibitor is underexplored, especially through computational studies. Using molecular docking, several promising candidates were identified with strong predicted binding to both targets. This study employs computational screening that provides a faster, more cost-effective, and greener path for the early stage of drug discovery. The findings provide valuable leads for the pharmaceutical industry, supporting the development of broad-spectrum therapeutics to improve treatment for patients with diabetes.